Definition

• Haemophilus influenzae type b (Hib) and nontypable H. influenzae are the most clinically important strains.
  • Hib causes systemic invasive disease in infants and children < 6 years of age.
    • Meningitis
    • Epiglottitis
    • Cellulitis
    • Pneumonia
  • Nontypable strains are primarily mucosal pathogens, occasionally causing invasive disease.
    • Pneumonia (adults)
    • Sinusitis (adults and children)
    • Otitis media (children)
    • Puerperal sepsis (neonates)
• H. influenzae biogroup aegyptius
  • Formerly called Haemophilus aegyptius
  • Causes Brazilian purpuric fever
  • Clinical manifestations
    • Purulent conjunctivitis followed by:
      • High fever, vomiting, abdominal pain
      • Petechiae, purpura, peripheral necrosis
      • Vascular collapse

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