Definition

• A systemic granulomatous disease of unknown etiology that can be acute or subacute and self-limited, or chronic, waxing and waning over many years
• Can involve all parts of the body; frequently involves
  
  • Lung
  • Skin
  • Eye
  • Liver
  • Lymph nodes
• Characteristics of affected organs
  
  • Accumulation of T lymphocytes and mononuclear phagocytes
  • Noncaseating epithelioid granulomas
  • Derangements of normal tissue architecture

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