Definition

• A systemic disease characterized by fever and abdominal pain and caused by Salmonella typhi or S. paratyphi
• The terms typhoid fever and enteric fever are now used interchangeably.
  
  • Typhoid fever was defined in the 1800s as a unique illness on the basis of its association with enlarged Peyer’s patches and mesenteric lymph nodes.
  • In 1869, given the anatomical site of infection, the term enteric fever was proposed as an alternative designation to distinguish typhoid fever from typhus.

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