Harrison's Practice

Liver Function Tests

Definition

  • Biochemical tests useful in evaluation and management of patients with hepatic dysfunction (See Table 296-1 for liver test patterns in hepatobiliary disorders.)
  • Tests that measure detoxification or excretory functions
    • Serum bilirubin
    • Urine bilirubin
    • Blood ammonia
    • Serum enzymes that reflect damage to hepatocytes
      • Aspartate aminotransferase (AST)
      • Alanine aminotransferase (ALT)
    • Serum enzymes that reflect cholestasis
      • Alkaline phosphatase (AP)
      • 5′-nucleotidase
      • Gamma glutamyl transpeptidase (GGT)
  • Tests that measure biosynthetic liver function
    • Serum albumin
    • Serum globulins
      • Gamma globulins (immunoglobulins)
      • Alpha globulins
      • Beta globulins
    • Coagulation factors
      • Serum prothrombin time
  • Other tests and procedures that may be necessary to make proper diagnosis of liver disease
    • Percutaneous biopsy of the liver
    • Ultrasonography
    • CT scan

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Liver Function Tests
Last updated: January 21, 2009
Content Manager
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